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Coloring cubes in a large cube with restrictions

Source: Problem 3 from Regional Olympiad of Mexico Southeast 2024

September 29, 2024
combinatoricscubeColoringMexico

Problem Statement

A large cube of size 4×4×44 \times 4 \times 4 is made up of 64 small unit cubes. Exactly 16 of these small cubes must be colored red, subject to the following condition:
In each block of 1×1×41 \times 1 \times 4, 1×4×11 \times 4 \times 1, and 4×1×14 \times 1 \times 1 cubes, there must be exactly one red cube.
Determine how many different ways it is possible to choose the 16 small cubes to be colored red.
Note: Two colorings are considered different even if one can be obtained from the other by rotations or symmetries of the cube.